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California Initiative to Advance Precision Medicine Demonstration Projects

CIAPM's portfolio of demonstration projects comprises broad collaborative efforts across institutions and sectors. The activities range from discovery to clinical implementation, aiming to enable more precise, individually targeted prevention, diagnosis, and treatment of disease, and to illustrate that precision medicine is making a difference now.

Open Funding Opportunity

Request for Proposals related to Depression and Mental Health
The California Initiative to Advance Precision Medicine (CIAPM) team, which is part of the Governor’s Office of Planning and Research, will release a Request for Proposals (RFP) on precision medicine approaches for the prevention, diagnosis, and treatment of depression in late September 2023.
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Current Projects

Adverse Childhood Experiences
CIAPM has awarded over $20 million to seven projects to address the health impacts of Adverse Childhood Experiences through a collaborative precision medicine approach.
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Improving Breast Cancer in Latinas: A Multi-Tiered Approach
This project aims to better understand the role of genetics in Latinas who develop breast cancer, and to increase community awareness of hereditary cancer risk and genetic testing.
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Integrated Machine-Learning Platform to Inform Precision Therapy in Breast Cancer Patients
This project applies precision medicine genomic profiling to find new treatments and to better match certain kinds of breast tumors to cancer existing therapies.
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Reducing Cancer Disparities Through Innovative Community-Academic Partnerships
The objective of this project is to develop, implement, and evaluate a Community Health Worker approach to cancer care that increases access to precision medicine at every stage of treatment.
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Completed Projects

Artificial Intelligence for Imaging of Brain Emergencies
This project successfully used artificial intelligence to automate brain scan evaluation.
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Early Prediction of Major Adverse Cardiovascular Events Using Remote Monitoring
This project monitored several types of patient data, including information from wearable health devices, to better predict who may be about to have a heart attack or stroke.
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Early Prostate Cancer: Predicting Treatment Response
This project focused on improving predictions about what treatment would work best for patients with early stage prostate cancer.
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Full Genome Analysis to Guide Precision Medicine
This project created a method that more thoroughly reads the entire human genome than all other available techniques.
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Precision Medicine for Multiple Sclerosis: Making it Work
This project developed an interactive digital tool to guide treatment decisions for multiple sclerosis patients that aligned with their experience, preferences, and priorities.
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Personal Mobile and Contextual Precision Health
This project developed a mobile health application to collect patient-reported data about blood pressure, mood, movement, and medication adherence.
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Precision Diagnosis of Acute Infectious Diseases
This project prepared a new method of infectious disease testing for use in clinical laboratories.
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California Kids Cancer Comparison
This project improved pediatric cancer care with novel, RNA-based treatment approaches; and by using large data sets to compare tumors between patients.
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Evaluations Report
A thorough, scientific review of CIAPM's first eight projects from a panel of experts.
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RFP Documents

Adverse Childhood Experiences (December 2019)
Full RFP
download pdf
Adverse Childhood Experiences (December 2019)
Proposal submission guidelines
download pdf
Cancer Disparities (July 2018)
Full RFP
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Cancer Disparities (July 2018)
RFP review process
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For More Information

David Reiner, PhD
David Reiner is a Science Officer within the California Initiative to Advance Precision Medicine.
david.reiner@opr.ca.gov